The Spooniverse: Comprehensive Infrastructure for Patients and Caregivers

Question 1: What percentage of people with Long COVID are estimated to meet the diagnostic criteria for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)?

~5%~10%~50%~75%

Question 2: What percentage of people with Long COVID are estimated to meet the diagnostic criteria for postural orthostatic tachycardia syndrome (POTS)?

~5%~10%~50%~67%

Question 3: A 35 yo man reports disabling fatigue, cognitive impairment, and shortness of breath that began after a suspected COVID-19 infection. Your attending diagnoses the patient with Long COVID and begins assessing him for the two most common infection-associated chronic illnesses seen in Long COVID which are:

ME/CFS and POTSType I diabetes and EBVPulmonary fibrosis and microclotting

Question 4: A 14yo girl with post-COVID myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) presents with dizziness on standing, headaches, purple toes, and tachycardia. For what common comorbidity of ME/CFS should the patient be assessed?

Mast cell activation syndrome (MCAS)Small intestinal bacterial overgrowth (SIBO)Postural orthostatic tachycardia syndrome (POTS)Multiple sclerosis (MS)

Question 5: A man in his 30s reports allergic reactions to previously tolerated foods, with rash and digestive distress. The patient has a history of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and postural orthostatic tachycardia syndrome (POTS). What common comorbidity of these conditions was likely missed?

Mast cell activation syndrome (MCAS)ShinglesSmall fiber neuropathy (FNS)Hypermobile ehlers-danlos syndrome (hEDS)

Question 6: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), postural orthostatic tachycardia syndrome (POTS), hypermobile ehlers danlos syndrome (hEDS), mast cell activation syndrome (MCAS), multiple sclerosis (MS), chronic lyme (PTLD) are all examples of what type of illness?

Cardiovascular diseasesGastrointestinal disordersInfection-associated chronic illnessesDegenerative neuromuscular diseases

Question 7: Which of the following represent onset in people with infection-associated chronic illnesses? Choose all that apply:

A single infection leading to lasting symptoms (acute onset)A single adverse health event leading to lasting symptoms (acute onset)Multiple adverse health events from which the patient never fully recovers (punctuated onset)Gradual onset over a long period of time

Question 8: Your patient had a diagnosed case of SARS-CoV-2. Three months later, they report fatigue, weakness and debility after exertion, and trouble thinking clearly. They received a Long COVID diagnosis. They would likely receive treatment and management advice for which disease or disorder?

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)Postural orthostatic tachycardia syndrome (POTS)Mast cell activation syndrome (MCAS)Type II Diabetes

Question 9: Your attending asks the following questions of a patient with suspected infection-associated chronic illness: "What happens after you engage in physical or mental exertion? Do you feel rested after sleep? Do you have trouble thinking clearly lately?" What disease are they asking about?

Hypermobile ehlers-danlos syndrome (hEDS)Mast cell activation syndrome (MCAS)Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)Postural orthostatic tachycardia syndrome (POTS)

Question 10: Your attending asks the following questions of a patient with suspected infection-associated chronic illness: "Is your dizziness worse when standing still? Do you have trouble thinking clearly lately?" What disease are they asking about?

Mast cell activation syndrome (MCAS)Postural orthostatic tachycardia syndrome (POTS)FibromyalgiaHypermobile ehlers-danlos syndrome (hEDS)

Infection-Associated Chronic Conditions Quiz