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Rintatolimod (Ampligen) for ME/CFS | The Spooniverse

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Treatment Database

Evidence-based and investigational interventions for Long COVID, ME/CFS, POTS, MCAS, fibromyalgia, and related conditions.

Evidence

What the ratings mean

Evidence-Based: Supported by multiple RCTs or systematic reviews demonstrating consistent benefit.
Emerging: At least one well-designed study (RCTs, observational with comparator group, or prospective/retrospective cohort) shows a directional benefit.
Experimental: Clinical data is absent or limited to case series, case reports, or surveys. Rationale is primarily mechanistic, preclinical, or extrapolated.
Inconclusive: Studied in controlled conditions, but results are null, contradictory, or mixed across trials. The available evidence does not resolve the question.

Condition

Type

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Showing 1 of 107 available treatments

Symptoms Addressed

Exercise intoleranceFatigueBrain fogPEM

Potential Side Effects

Dry skinTachycardiaHeadachesChillsFeverFlu-like syndrome

Mechanism of Action

TLR3 agonist; dendritic cell activation; modulates T effector/T regulatory cell ratio; antiviral

Evidence Type(s)

RCT, Post-hoc subgroup analysis

Key References

PMID:22431963 PMID:33119613

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